Prediction of Hot Spots by Using Structural Neighborhood Properties

PredHS2, a computational method that can effectively identify hot spots on protein-protein interaction interfaces by using Extreme Gradient Boosting. The previous version of PredHS is available here.

Usage Notes: the upload PDB file should be a complex (contain at least two proteins/chains). The computing time depends on the number of residues of the protein complex. Most predictions will be finished in 5-30 minutes. Here is a pre-calculated example to display the prediction results: 1CDL

Upload your structure files

files must be in PDB-like format and ended in ".pdb", maximum allowed 10 files uploaded at a time

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an example of protein structure file

For questions about PredHS2 server, please email Lei Deng for assistance.